Trial reportFrontiers in nutrition2025
Effect of a new plant-based high-energy oral nutritional supplement in adult malnourished patients: an open-label, randomized clinical trial.
Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06055543 (Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients
Who cites it
1 citing paper in PubMed.
- Sensory Acceptability and Sensory Profiles of Flavoured Foods for Special Medical Purposes: A Quantitative Descriptive Analysis.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: The recent global trend toward reducing the consumption of animal-derived products has contributed to a growing demand for plant-based oral nutritional supplement (pbONS) options. PbONS, in addition to achieving good compliance, have an improvement in nutritional status (increased energy and protein intake, body weight, and BMI) on malnourished patients. However, there is no evidence of their impact compared to animal-based ONS (aONS). Methods: A multicenter, open-label, and non-inferiority trial (NCT06055543) was conducted in 5 tertiary hospitals in Spain. Adult malnourished outpatients requiring high-energy ONS for at least 12 weeks (1.5 kcal/ml;200 ml, 2 bottles/day), having signed informed consent, were recruited and randomly assigned (1:1) to receive pbONS or aONS. Randomization was performed using a pre-generated list embedded in the electronic data entry platform. The total number of participants randomized was 149, 75 patients in aONS group and 74 in pONS group. Baseline and final characteristics of the two groups were described and compared in terms of sociodemographic, clinical, compliance, and satisfaction variables. Results: A total of 129 patients who received pbONS (66) or aONS (74) were included. Weight increased significantly from 55.1 ± 12.7 kg to 57.4 ± 13.1 kg ( Conclusion: PbONS are as effective and well-tolerated as traditional ONS in improving nutritional outcomes, with high patient satisfaction in malnourished patients. This study provides valuable evidence for integrating pbONS into routine clinical practice for the tailored management of patients. Clinical trial registration: The study was registered on September 21, 2024, with the identifier number NCT06055543.
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