ArticleJournal of transplantation2025
Evaluation of Intraoperative Gentamicin Bladder Irrigation for Mitigation of Urinary Tract Infections After Kidney Transplantation: A Propensity Score-Matched Analysis of a Randomized Controlled Trial.
Article in Journal of transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Background: Urinary tract infections (UTIs) remain the leading infectious complication after kidney transplantation. We evaluated intraoperative gentamicin bladder irrigation as a novel preventive strategy. Methods: In this randomized, double-blind controlled trial at a tertiary transplant center (January-December 2021), 147 kidney transplant recipients were randomized to receive intraoperative bladder irrigation with gentamicin (160 mg/250 mL) or saline during ureteroneocystostomy. Due to baseline imbalances, propensity score matching yielded 49 matched pairs. The primary endpoint was UTI incidence within 30 days post-transplant, defined by both microbiological (≥ 10 Results: UTI incidence was 26.5% (13/49) in controls versus 16.3% (8/49) with gentamicin (absolute risk reduction 10.2%, Conclusions: Intraoperative gentamicin bladder irrigation safely reduced early post-transplant UTIs by 38.5%, with efficacy in female recipients. While underpowered for statistical significance, the clinically meaningful effect size and excellent safety profile support considering this intervention for high-risk recipients, especially females, pending larger confirmatory trials.
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