ArticleJournal of pain research2025
Shared Genetic Architecture of Obstructive Sleep Apnea and Neck Pain: A Large-Scale Genome-Wide Association Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to explore the role of genetic factors in the co-occurrence of neck pain and obstructive sleep apnea (OSA), thereby providing a deeper understanding of their intrinsic relationship. Methods: We analyzed GWAS data for OSA from the FinnGen consortium (38,998 cases and 336,659 controls), and neck pain from the UK Biobank (106,521 cases and 355,336 controls), all of European ancestry. Genetic correlation between neck pain and OSA using the Linkage Disequilibrium Score Regression (LDSC) method and High-definition Likelihood (HDL) method. Local correlation was examined across 2,795 loci with Local Analysis of Variant Association (LAVA). Mendelian randomization (MR) was conducted to infer causality. Cross-Phenotype Association (CPASSOC) identified pleiotropic SNPs, which were annotated with FUMA and validated by MAGMA. Transcriptome-wide association study (TWAS) and tissue enrichment analyses were further applied to explore biological mechanisms. Results: MR analysis indicated that NP increases the risk of OSA. CPASSOC identified 150 pleiotropic SNPs, with 40 loci annotated by FUMA, yielding 85 pleiotropic genes consistent with MAGMA. TWAS highlighted seven genes with significant pleiotropic effects on both NP and OSA. Tissue enrichment revealed that pleiotropic gene expression was predominantly localized in brain tissues, particularly the cerebral cortex (P=2.17E-6). These genes suggested involvement of neurodevelopmental and metabolic pathways in neck pain-OSA comorbidity. In MR,we found that individuals with neck pain had an increased risk of developing OSA. Conclusion: Our findings underscore the pivotal role of genetic factors in neck pain-OSA comorbidity and provide theoretical support for considering pain management as part of clinical strategies for OSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.