ArticleClinical case reports2025
Metformin-Associated Lactic Acidosis Following Acute Overdose: Clinical Course and Conservative Management.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Severe Metformin Intoxication Resulting in Extreme Lactic Acidosis.Journal of medical cases · 2026Article
- Metformin-Associated Lactic Acidosis Following Acute Overdose: Clinical Course and Conservative Management.Clinical case reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metformin is an antidiabetic medication that belongs to the class of oral hypoglycemic agents: Biguanides. Although its mechanism of action remains elusive, it is well established that metformin enhances insulin sensitivity and decreases hepatic gluconeogenesis. Metformin usually does not provoke hypoglycemia and is well tolerated. Despite this fact, metformin-associated lactic acidosis (MALA) remains one of the concerning side effects especially in the context of tissue hypoxia and pre-existing renal failure. Management usually involves maintenance of hemodynamic stability, correction of acidosis and even renal replacement therapy in refractory cases. This case report aims to improve understanding and clinical presentation of this infrequent entity and also highlights the importance of a robust diagnostic approach in the management of the same.
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Registered trials
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