Evidence map›Paper›PMID 41356639›Full record

ArticleClinical case reports2025

Neuroleptic Malignant Syndrome on Chronic Trifluoperazine Therapy: A Diagnostic Dilemma.

Sagun Baral, Sushmita Bhattarai, Khem Chandra Joshi

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sagun BaralDepartment of Internal Medicine Rapti Academy of Health Sciences Dang Nepal.ORCID https://orcid.org/0009-0005-5980-9335
Sushmita BhattaraiDepartment of Internal Medicine Rapti Academy of Health Sciences Dang Nepal.ORCID https://orcid.org/0009-0001-4450-4791
Khem Chandra JoshiDepartment of Internal Medicine Rapti Academy of Health Sciences Dang Nepal.ORCID https://orcid.org/0009-0007-3583-205X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroleptic malignant syndrome (NMS) is a rare, life-threatening reaction to antipsychotic medication. This report describes the case of a 62-year-old male with chronic trifluoperazine use who presented with fever, rigidity, and altered mental status. Although sepsis or meningoencephalitis was initially suspected, an elevated creatine kinase and fulfillment of Levenson's criteria confirmed the diagnosis of NMS. The patient's condition improved following supportive care, administration of bromocriptine, and lorazepam. This case highlights the diagnostic challenges of NMS in patients on a stable antipsychotic regimen and underscores the importance of early recognition, particularly after excluding infectious etiologies.

Indexed as

antipsychoticscreatine kinaseencephalopathyneuroleptic malignant syndrometrifluoperazine

Identifiers

PMID41356639
PMCPMC12680485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.