Evidence map›Paper›PMID 41356593›Full record

ArticleWorld journal of cardiology2025

Prehospital aspirin use is associated with improved clinical outcomes in pulmonary embolism: A retrospective case-control study.

Mithil Gowda Suresh, Safia Mohamed, Harinivaas Shanmugavel Geetha, Akshaya Sekar, Sushmita Prabhu, Jennifer Sargent, George M Abraham, Juniali Hatwal, Akash Batta, Bishav Mohan

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Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Mithil Gowda SureshDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
Safia MohamedDepartment of Medicine and Surgery, University of Massachusetts Chan Medical School-Baystate Medical Center, Springfield, MA 01199, United States.
Harinivaas Shanmugavel GeethaDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
Akshaya SekarDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
Sushmita PrabhuDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
Jennifer SargentDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
George M AbrahamDepartment of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.
Juniali HatwalDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Akash BattaDepartment of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com.
Bishav MohanDepartment of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary embolism (PE) is a leading cause of cardiovascular mortality. Although anticoagulation is the cornerstone of treatment, aspirin's potential to modulate thromboinflammation and improve outcomes in non-surgical PE patients remains underexplored.

aimTo assess whether prehospital aspirin use is associated with improved outcomes in patients hospitalized with acute PE.

methodsWe conducted a retrospective case-control study of 323 adult patients admitted with computed tomography-confirmed acute PE from January 2020 to December 2023. Patients were stratified according to documented daily aspirin use for ≥ 7 days prior to hospital admission. Primary outcomes included right ventricular strain, intensive care admission, shock, mechanical ventilation, and in-hospital mortality. Univariate logistic regression was used. A

resultsTotal of 323 patients, 90 (27.9%) used aspirin prehospital. Aspirin users were older (74.2 ± 14.3 years

conclusionPrehospital aspirin use is associated with reduced severity and mortality in acute PE. These findings support a potential protective role for aspirin and warrant validation in prospective, multicenter trials.

Indexed as

Antiplatelet therapyAspirinIntensive care unitMortalityPulmonary embolismRight ventricular strainShock

Identifiers

PMID41356593
PMCPMC12678870

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