Evidence map›Paper›PMID 41356588›Full record

ReviewWorld journal of cardiology2025

Lysosomal acid lipase deficiency: The forgotten link between liver and cardiovascular disease.

Paolo Fornengo, Arianna Ferro, Sharmila Fagoonee, Elisa Rinaudo, Cristina Amione, Marilena Durazzo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paolo FornengoDepartment of Medical Sciences, University of Turin, Turin 10126, Piedmont, Italy.
Arianna FerroDepartment of Medical Sciences, University of Turin, Turin 10126, Piedmont, Italy.
Sharmila FagooneeInstitute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center "Guido Tarone", Turin 10126, Piedmont, Italy.
Elisa RinaudoDepartment of Medical Sciences, University of Turin, Turin 10126, Piedmont, Italy.
Cristina AmioneServizio di - Diabetologia e Malattie Metaboliche, Ospedale degli Infermi, Biella 13875, Piedmont, Italy.
Marilena DurazzoDepartment of Medical Sciences, University of Turin, Turin 10126, Piedmont, Italy. marilena.durazzo@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomal acid lipase-deficiency (LAL-D) is a rare and systemic condition, secondary to lipase A gene mutations, responsible for lysosomal accumulation of cholesteryl esters and triglycerides in many tissues. It is a very heterogeneous disease in terms of the age of onset, severity, and the type of clinical and radiological manifestations. Dyslipidemia, hepatomegaly, and hepatosteatosis with increased levels of transaminases are the most common features. In association with liver dysfunction and evolution to cirrhosis, there is an increased risk of premature atherosclerosis and cardiovascular disorders, secondary to a generalized alteration of lipid profile and lipoprotein dysfunction associated with LAL-D. Therefore, we provide an update on the frequently under-recognized LAL-D, focusing on the late-onset form: Cholesteryl ester storage disease.

Indexed as

Cholesteryl ester storage diseaseDyslipidemiaLipase ALysosomal acid lipase deficiencyNon-alcoholic fatty liver disease

Identifiers

PMID41356588
PMCPMC12678881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.