ArticleFrontiers in parasitology2025
Assessing the performance of TRX and DUF148 antigens for detection of prepatent Guinea worm (
Article in Frontiers in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Guinea worm (GW) is a nematode that causes a neglected tropical disease that is targeted for eradication. GW emergence in animals, particularly dogs, has hampered eradication efforts. Currently, there is no method for diagnosing GW infection in animals during the prepatent period. Previous work has identified two immunoreactive antigens, TRXL-1 (TRX) and DUF148. Methods: This study developed and assessed the performance of an indirect ELISA using these antigens. Results: Using serum samples from experimentally exposed dogs, TRX and DUF148 showed reactivity at 9- and 11-weeks post-exposure, respectively. These antigens were further assessed using sera of dogs from GW-endemic villages in Chad (n=47) and shelter dogs from the non-endemic United States (n=492). DUF148 showed better reactivity and sensitivity of 76.6.% in detecting GW infection in prepatent sera compared to TRX. However, DUF148 cross-reacted with a Discussion: Our findings could facilitate the development of diagnostic methods for early detection of GW infection in dogs in endemic countries.
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