Evidence map›Paper›PMID 41356539›Full record

ArticleClinics in orthopedic surgery2025

Acetaminophen Inhibits Fatty Infiltration without Impairing Tendon-Bone Interface Healing in a Rat Model of Acute Rotator Cuff Repair.

Jong Pil Yoon, Sung-Jin Park, Dong-Hyun Kim, Yoon Seong Choi, Hyun Joo Lee, Jun-Young Kim, Chul-Hyun Cho, Seok Won Chung

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Article in Clinics in orthopedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jong Pil YoonDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0001-6446-6254
Sung-Jin ParkDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0008-6869-0788
Dong-Hyun KimDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0001-9078-5953
Yoon Seong ChoiDepartment of Carbon Hybrid Fiber Science, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0006-1483-0023
Hyun Joo LeeDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0003-2837-3434
Jun-Young KimDepartment of Orthopedic Surgery, Daegu Catholic University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-4700-3041
Chul-Hyun ChoDepartment of Orthopedic Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-0252-8741
Seok Won ChungDepartment of Orthopedic Surgery, Konkuk University Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8221-9289

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgroud: Rotator cuff (RC) tears are a common shoulder disorder associated with pain, dysfunction, and progressive muscle degeneration. Postoperative muscle atrophy and fatty infiltration are key factors contributing to poor healing outcomes, increased rerupture rates, and long-term functional impairment. While acetaminophen (APAP) is widely used for pain management, its potential effects on muscle fatty infiltration and tendon-bone interface (TBI) healing remain unclear. This study aimed to investigate whether APAP influences fatty infiltration and TBI healing after RC surgery. We hypothesized that APAP would reduce fatty infiltration by downregulating peroxisome proliferator-activated receptor gamma (PPAR-γ) while preserving histological and biomechanical TBI integrity. Methods: A RC repair rat model was created using 12-week-old male Sprague-Dawley rats. Ten rats in the APAP group received an oral dose of 30 mg/kg APAP daily for 4 weeks after RC tendon transection, and 10 rats in the control group were administered only 0.9% saline. All rats were sacrificed 4 weeks after surgery. Fatty infiltration was analyzed qualitatively and quantitatively in the proximal part of the supraspinatus muscle. TBI was evaluated for RC healing effect through general tissue staining and biomechanical strength measurements. Results: Four weeks after tendon repair, the APAP group showed significant prevention of supraspinatus fatty infiltration compared to the control group ( Conclusions: APAP treatment was associated with prevention of supraspinatus fatty infiltration without adversely affecting TBI healing in an RC repair model.

Indexed as

AcetaminophenAdipose TissueAnalgesics, Non-NarcoticRotator CuffRotator Cuff InjuriesWound HealingAnimalsDisease Models, AnimalMalePPAR gammaRatsRats, Sprague-DawleyAcetaminophenAnalgesics, Non-NarcoticPPAR gammaAcetaminophenBiomechanical analysisFatty infiltrationHistological analysisRotator cuff tear

Identifiers

PMID41356539
PMCPMC12676917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.