Evidence map›Paper›PMID 41356526›Full record

ArticleWorld journal of gastroenterology2025

Dexmedetomidine enhances anastomotic healing partly

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

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Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ying ChenDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.
Chun-Tian LiDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.
Jie-Bo WangDepartment of Anaesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China.
Wen-Lu TangDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.
Yu ZhaoDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.
Ye ChenDepartment of Anaesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China.
Lian-Ming LiaoDepartment of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China.
Liang-Cheng ZhangDepartment of Anaesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China.
Tian-Hua LinDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China. linthua2001@126.com.
Zhi-Fang CaoDepartment of Anaesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal surgery is often associated with a high risk of anastomotic leakage. Intraoperative administration of dexmedetomidine (DEX) can improve postoperative gastrointestinal function.

aimTo investigate the effects of DEX on anastomotic healing in a rat model of intestinal anastomosis (IA).

methodsRats were randomly divided into three groups: Sham (underwent abdominal only opening and closure), IA, and IA + DEX. In the IA + DEX group, DEX (5 μg/kg) was administered

resultsCompared with IA, IA + DEX showed a non-significant increase in intestinal propulsion on postoperative day 6 and a significant rise in anastomotic burst pressure on day 7. Histology indicated reduced inflammation and submucosal injury. Serum tumor necrosis factor-alpha and diamine oxidase decreased, while tight junction proteins (claudin-1, ZO-1) increased in IA + DEX. High-throughput sequencing and Western blotting suggested activation of the Wnt/β-catenin pathway as a potential mechanism.

conclusionDEX enhances anastomotic healing and barrier function after IA, partly

Indexed as

Anastomotic LeakColonDexmedetomidineWnt Signaling PathwayWound HealingAnastomosis, SurgicalAnimalsApoptosisbeta CateninCell LineDisease Models, AnimalGlycogen Synthase Kinase 3 betaIntercellular Signaling Peptides and ProteinsIntestinal MucosaMaleRatsbeta CateninCtnnb1 protein, ratDexmedetomidineDkk1 protein, ratGlycogen Synthase Kinase 3 betaIntercellular Signaling Peptides and ProteinsDexmedetomidineIntestinal anastomosisSignaling pathwayTight junction proteinsWnt/β-catenin

Identifiers

PMID41356526
PMCPMC12678982

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