Case Report: Multifocal Epithelial Hyperplasia in Two Yemeni Patients With Khat Chewing Habits.

Layla Hafed, Munia Mahmood Shamsheer, Islam Alobaidy, Eman Abdullah S Al-Salami, Fathia Gazem S Awadhi, Hind Arhab, Aisha A H Al-Jamaei

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Article in Case reports in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Layla HafedDepartment of Oral Medicine and Diagnostic Science, Faculty of Dentistry, Saba University, Sana'a, Yemen.ORCID https://orcid.org/0000-0002-5362-7734

Munia Mahmood ShamsheerDepartment of Oral Medicine, Periodontology, and Radiology, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.ORCID https://orcid.org/0009-0006-5952-5508

Islam AlobaidyDepartment of Oral Medicine, Periodontology, and Radiology, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.ORCID https://orcid.org/0009-0004-1056-0703

Eman Abdullah S Al-SalamiHistopathology and Tumors Department, Al-Mamoon Diagnostic Medical Center, Sana'a, Yemen.ORCID https://orcid.org/0009-0003-8949-5504

Fathia Gazem S AwadhiDermatology Department, Al-Mamoon Diagnostic Medical Center, Sana'a, Yemen.ORCID https://orcid.org/0009-0000-3519-0615

Hind ArhabDepartment of Oral Medicine, Periodontology, and Radiology, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.ORCID https://orcid.org/0009-0009-9217-5628

Aisha A H Al-JamaeiDepartment of Oral Medicine, Periodontology, and Radiology, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.ORCID https://orcid.org/0000-0002-2692-0142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifocal epithelial hyperplasia (MEH) represents a benign condition associated with human papillomavirus. This condition is notably uncommon and primarily affects specific demographic groups, particularly children and adolescents. Within Yemen, similar to other Asian regions, the condition remains relatively uncommon. The lesions typically manifest intraorally on the labial and buccal mucosa as well as the tongue. In this report, we present two cases, where MEH was observed on the vermillion surface of the lips in adult patients. Several possible risk factors were identified in these cases, including socioeconomic disadvantage, khat chewing, and liver dysfunction. These findings emphasize the importance of considering MEH in the differential diagnosis of papillary lesions affecting the vermillion surfaces of the lips.

Identifiers

PMID41356492

DOI10.1155/crid/8090225

PMCPMC12680460

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