Evidence map›Paper›PMID 41356478›Full record

ArticleFrontiers in microbiology2025

Genistein supplementation modulates the intestinal microbiota-liver-lumbar muscle metabolic axis in DLY commercial pigs without concomitant changes in growth performance.

Yong Du, Yiting Yang, Yan Wang, Yuanyuan Wu, Chengming Liu, Ziling Hao, Zhijuan Yan, Junxiang Mao, Jiaqi Wen, Ye Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yong Du *Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yiting Yang *Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yan WangFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yuanyuan WuDepartment of Biological Engineering, Sichuan Fisheries School, Chengdu, China.
Chengming LiuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Ziling HaoFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Zhijuan YanFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Junxiang MaoFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Jiaqi WenFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Ye ZhaoFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Lili NiuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Xiaofeng ZhouFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Linyuan ShenFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Li ZhuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Mailin GanFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genistein is widely found in leguminous plants. As an isoflavone, it has functions similar to mammalian estrogen and has effects on many aspects such as animal carcass performance, intestinal flora composition and physiological metabolism. This study aimed to investigate the effects of genistein supplementation on the carcass performance of commercial pigs via intestinal microorganisms, liver and lumbar muscle metabolites. Sixteen DLY commercial pigs were divided into two groups: a fed group receiving a diet supplemented with 160 mg/kg genistein and a control group without supplementation; the intervention lasted about 74 days. The bacterial genome of the 16SrRNA V3-V4 region was sequenced to observe the diversity and composition changes of microorganisms in the feces of the fed group and the control group. At the same time, the differential metabolites and metabolic pathways of the liver and lumbar muscle tissues of the fed group and the control group were jointly analyzed. The results of the study showed that the addition of genistein to feed can increase the relative abundance of

Indexed as

16SrRNA sequencinggenisteinliver metabolomelumbar muscle metabolismswine production

Identifiers

PMID41356478
PMCPMC12675160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.