Evidence map›Paper›PMID 41356431›Full record

ArticleNpj biological timing and sleep2025

Adaptive introgression in modern human circadian rhythm genes.

Christopher Kendall, Amin Nooranikhojasteh, Guilherme Debortoli, Vinicius Cauê Furlan Roberto, Marla Mendes, David Samson, Esteban Parra, Bence Viola, Michael A Schillaci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher KendallNeurosciences and Mental Health Department, The Hospital for Sick Children, Toronto, ON Canada.
Amin NooranikhojastehEpigenome Lab, Princess Margaret Cancer Centre, University Health Network, Toronto, ON Canada.
Guilherme DebortoliDepartment of Anthropology, University of Toronto Mississauga, Mississauga, ON Canada.
Vinicius Cauê Furlan RobertoThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON Canada.
Marla MendesThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON Canada.
David SamsonDepartment of Anthropology, University of Toronto Mississauga, Mississauga, ON Canada.
Esteban ParraDepartment of Anthropology, University of Toronto Mississauga, Mississauga, ON Canada.
Bence ViolaDepartment of Anthropology, University of Toronto, Toronto, ON Canada.
Michael A SchillaciDepartment of Anthropology, University of Toronto Scarborough, Scarborough, ON Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interbreeding between modern humans and archaic hominins, including Neanderthals and Denisovans, occurred as modern humans migrated outside of Africa. Here, we report on evidence of adaptive introgression from archaic hominins within genomic regions associated with circadian rhythm cycling, chronotype, and sleep using 76 worldwide modern human populations from the Human Genome Diversity Project and 1000 Genomes Project. We identified 265 independent segments suggestive of adaptive introgression, where 22 of these segments show evidence of positive selection. We tested for evidence of a latitudinal cline within 35 core haplotypes, finding no clear latitude gradient, and identified the likely archaic donor for each of these haplotypes. We found that several genes with evidence of adaptive introgression are associated with affective disorders, chronotype, and respiratory diseases. Lastly, many of the variants are eQTLs for several genes that are significantly enriched in immunity pathways.

Indexed as

Bipolar disorderCircadian mechanismsCircadian regulationCircadian rhythmsPsychiatric disorders

Identifiers

PMID41356431
PMCPMC12678189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.