Evidence map›Paper›PMID 41356417›Full record

ArticleMaterials today. Bio2025

Mild photothermal-mediated neuroimmunomodulatory composite hydrogel ameliorates bone healing microenvironment for enhanced osteoporotic bone defect regeneration.

Qingcheng Song, Shuo Zhang, Jiahao Yu, Yiran Zhang, Chunxu Fu, Xin Xing, Jianhua Wu, Yanbin Zhu, Wei Chen, Yingze Zhang

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Biological Applications of Functionalized Cerium Oxide Nanoparticles.International journal of medical sciences · 2026
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qingcheng SongDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Shuo ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Jiahao YuDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Yiran ZhangDepartment of Hand and Foot Surgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong, 518000, China.
Chunxu FuSchool of Medicine, Nankai University, Tianjin, 300071, China.
Xin XingDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Jianhua WuThe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, China.
Yanbin ZhuDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Wei ChenDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Yingze ZhangDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of osteoporotic bone defects represents a substantial clinical challenge in contemporary orthopedics due to the abnormal accumulation of reactive oxygen species (ROS) and elevated inflammatory levels. Despite advances in bone graft materials for enhancing bone regeneration, developing an ideal therapeutic strategy capable of orchestrating the multidimensional biological processes underlying bone healing, such as immunomodulation, angiogenesis, osteogenesis and innervation, remains a formidable challenge in orthopedic biomaterial design. In our study, a multifunctional composite hydrogel (Ce@Mo/GC) was developed through the incorporation of CeO

Identifiers

PMID41356417
PMCPMC12676112

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.