Evidence map›Paper›PMID 41356378›Full record

ArticleWorld journal of stem cells2025

Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration.

Jing-Shun Lu, Yun-Hong Zhao, Fei-Yan Mu, Chen-Yu Song, Min Yang, Yuan-Sheng Huang, Kai-Yang Wang

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing-Shun LuDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China.
Yun-Hong ZhaoSouthern Central Hospital of Yunnan Province, The First People's Hospital of Honghe State, Mengzi 661100, Yunnan Province, China.
Fei-Yan MuSouthern Central Hospital of Yunnan Province, The First People's Hospital of Honghe State, Mengzi 661100, Yunnan Province, China.
Chen-Yu SongDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Min YangDepartment of Traditional Chinese Medicine, Meilong Community Health Service Center of Minhang District, Shanghai 200233, China.
Yuan-Sheng HuangDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China.
Kai-Yang WangDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. ortho_wang@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells that serve as progenitors for connective tissue and have emerged as a crucial resource in the field of tissue engineering owing to their capacity to differentiate into multiple cell lineages. MSCs-based bone regeneration strategies hold immense therapeutic potential, yet their efficacy is critically limited by inefficient osteogenic differentiation. Mounting evidence positions mitochondria as central regulators of this process, extending beyond their traditional role as cellular powerhouses. Mitochondrial regulation not only influences the induction rate of MSCs differentiation, but also determines the differentiation pathway and the ultimate fate of the resulting cells. To date, research in bone regeneration engineering has predominantly focused on the application of stem cell-based biomaterials, with limited attention given to mitochondrial development. We aim to provide a novel research perspective for targeted mitochondrial interventions in bone regeneration engineering by elucidating the mechanisms through which mitochondria regulate osteogenic differentiation of MSCs.

Indexed as

Bone regenerationMesenchymal stem cellsMitochondrialMitophagyOxidative stress

Identifiers

PMID41356378
PMCPMC12679221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.