Evidence map›Paper›PMID 41356370›Full record

ArticleResearch square2025

MASLD and MASH increase fracture risk in humans and mice by arresting new bone formation.

Galen Goldscheitter, Vinay Jahagirdar, Mulugeta Seneshaw, Faridoddin Mirshahi, Morgan Summerlin, Allison Ip, Austin Coelho, Evan Buettmann, Damian Genetos, Arun Sanyal and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Galen GoldscheitterVirginia Commonwealth University School of Medicine.ORCID https://orcid.org/0000-0002-6721-3161
Vinay JahagirdarVirginia Commonwealth University School of Medicine.
Mulugeta SeneshawVirginia Commonwealth University School of Medicine.
Faridoddin MirshahiDiv. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA.
Morgan SummerlinGeorgia Institute of Technology.
Allison IpUniversity of Virginia.
Austin CoelhoYale University.
Evan BuettmannVirginia Commonwealth University.
Damian GenetosUniversity of California Davis College of Veterinary Medicine.
Arun SanyalVirginia Commonwealth University.ORCID https://orcid.org/0000-0001-8682-5748
Henry DonahueVirginia Commonwealth University College of Engineering.

Funding

Mouse Model and Pathological Analysis CoreP01CA275740 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ARUN J SANYAL · 2024 to 2026
$10.6M
Mechanobiology of fracture healing during skeletal disuseK99AR082989 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUETTMANN, EVAN G · 2023 to 2024
$224k
Breaking Down Bones: Hepato-skeletal crosstalk in MASLD-associated fracture susceptibilityF30DK143698 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI Galen Michael Goldscheitter · 2025 to 2026
$68k
NCI NIH HHS P01 CA275740NIAMS NIH HHS K99 AR082989NIDDK NIH HHS F30 DK143698
6 · The paper itself

Abstract

Early data suggest metabolic dysfunction-associated steatotic liver disease (MASLD) associates with increased fractures. However, absolute risk, subpopulations at greatest risk, and risk basis are unknown. We use a two-pronged approach to address these gaps: we investigated fracture risk among humans with MASLD and mechanisms among diet-induced animal model of NAFLD (DIAMOND

Indexed as

fractureinflammationMASLDskeletal metabolism

Identifiers

PMID41356370
PMCPMC12676449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.