Evidence map›Paper›PMID 41356366›Full record

ArticleResearch square2025

Stress-driven emergence of heritable non-genetic drug resistance.

Jinglin L Xie, Sifei Yin, Theodore S Yang, Kiran Chandrasekher, Luke Hanson, Sang Hu Kim, Lucas Esqueda, Catherine A Hogan, Niaz Banaei, June L Round and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jinglin L XieDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-7373-3449
Sifei YinDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Theodore S YangDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Kiran ChandrasekherDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Luke HansonDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Co, USA.
Sang Hu KimDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Lucas EsquedaDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Catherine A HoganDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Niaz BanaeiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
June L RoundDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, UT, USA.
Kyla S OstDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Co, USA.
Judith BermanShmunis School of Biomedical and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Britannia 418, Ramat Aviv Israel.ORCID https://orcid.org/0000-0002-8577-0084
Daniel F JaroszDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Protein-based Molecular Memories in Gene Regulation, Disease, and DevelopmentDP2GM119140 · NIGMS · STANFORD UNIVERSITY · PI JAROSZ, DANIEL · 2015 to 2015
$2.4M
Understanding and targeting non-genetic mechanisms of drug resistanceK99AI169076 · NIAID · STANFORD UNIVERSITY · PI XIE, JING LIN · 2023 to 2024
$242k
NIAID NIH HHS K99 AI169076NIGMS NIH HHS DP2 GM119140
6 · The paper itself

Abstract

Drug resistance is the chief cause of treatment failure for therapies targeting chronic and infectious diseases. Whether the emergence of resistance is accelerated by environmental exposure to low levels of therapeutics remains controversial. Here, we report a non-genetic mechanism of stress adaptation that promotes heritable resistance to the widely used antifungal drug fluconazole. In the human fungal pathogen

Identifiers

PMID41356366
PMCPMC12676448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.