Evidence map›Paper›PMID 41356359›Full record

ArticleResearch square2025

Pachytene piRNAs define a conserved program of meiotic gene regulation: Pachytene piRNAs directly regulate select mRNAs by and RNAi-like mechanism, establishing a regulatory paradigm of mammalian meiosis.

Zuzana Loubalova, Franziska Ahrend, Daniel Stoyko, Rachel Cosby, Sherry Ralls, Gunter Meister, Todd Macfarlan, Astrid D Haase

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zuzana LoubalovaNational Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Franziska AhrendNational Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Daniel StoykoNational Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Rachel CosbyThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health; Bethesda, Maryland, USA.
Sherry RallsThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health; Bethesda, Maryland, USA.
Gunter MeisterRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany.ORCID https://orcid.org/0000-0002-2098-9923
Todd MacfarlanThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health; Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-2495-9809
Astrid D HaaseNational Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-1120-9013

Funding

PIWI proteins and PIWI-interacting small RNAs guard the genomic integrity of germ cellsZIADK075111 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HAASE, ASTRID · 2015 to 2025
$14.7M
Intramural NIH HHS ZIA DK075111
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41356359
PMCPMC12676428

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.