Evidence map›Paper›PMID 41356341›Full record

ArticleBlood vessels, thrombosis & hemostasis2025

Tirsa T van Duijl, Samantha Gouw, Ina Kronevska, Alette Kooiker, Wil F Kopatz, Nadia Freato, Marlene Beijlevelt, Henrike M Hamer, Karin Fijnvandraat, Joost C M Meijers and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07454161 (Bleeding Disorder of Unknown Cause In the Netherlands), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07454161 recruitingnot on this mapstarted 2026, after this paper: background citation

Bleeding Disorder of Unknown Cause In the Netherlands (BDUC-iN Study)

Typeobservational_patient_registrySponsorMaastricht University Medical CenterRan2026 to 2039Enrolled500ConditionsHemorrhagic Disorders, Bleeding Disorder of Unknown Cause
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tirsa T van DuijlDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.
Samantha GouwDepartment of Pediatric Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Ina KronevskaDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.
Alette KooikerDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.
Wil F KopatzDepartment of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Nadia FreatoDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.
Marlene BeijleveltDepartment of Pediatric Hematology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Henrike M HamerSpecialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Karin FijnvandraatDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.
Joost C M MeijersDepartment of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Maartje van den BiggelaarDepartment of Bleeding and Hemostasis, Sanquin Research, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophilia B, a rare bleeding disorder, is caused by genetic variations in

Identifiers

PMID41356341
PMCPMC12680096

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.