ArticleFrontiers in human neuroscience2025
Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn's disease patients: explorative findings from a 7T MRS study.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
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9 authors.
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Abstract
Background: The bidirectional communication between the brain and gut in Crohn's disease is increasingly acknowledged, highlighting how gut inflammation can influence brain function and psychological health, and vice versa, through the gut-brain axis. The insula is critical for processing pain, its emotional evaluation, and for regulating neurometabolites involved in these processes. The role of insular neurometabolites in gastrointestinal symptoms, particularly pain, in Crohn's disease patients, however, is not well-understood, highlighting the need for further investigation. Therefore, this study aims to enhance our understanding of the connection between Crohn's disease and brain function by investigating neurometabolic profiles in the insula of patients with Crohn's disease. Methods: In this study, 7 Tesla proton magnetic resonance spectroscopy ( Results: No significant differences were found in the absolute concentrations of insular neurometabolites between Crohn's disease patients and healthy controls. However, in patients with Crohn's disease, GSRS scores were negatively correlated with the neurometabolites aspartate (Asp) and N-acetylaspartylglutamate (NAAG) in the insula. Furthermore, significant positive correlations were observed between scores on the PCS magnification subscale and concentrations of neurometabolites-namely glutamine (Gln) and the combined glutamate and glutamine signal (Glx) -as measured by ( Conclusion: The neurometabolic alterations observed in the insular cortex of Crohn's disease patients suggest increased insular activity, which may enhance interoceptive awareness and pain sensitivity, potentially contributing to heightened pain catastrophizing.
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