ArticleFood science & nutrition2025
Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.Food science & nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Danggui Buxue Decoction (DBD) has shown potential antitumor effects in a variety of cancers. This study aims to delve into the effects and mechanisms of DBD on the metastasis of triple-negative breast cancer (TNBC). The mouse model of TNBC was constructed, and the function of DBD was investigated. The active components and core targets of DBD on TNBC were identified through liquid chromatography-mass spectrometry, network pharmacology, and molecular docking techniques. A set of in vitro experiments was conducted to examine the key components and core targets of DBD that affect the metastasis of TNBC. DBD inhibited the growth and metastasis of TNBC tumors. Formononetin is one of the key active ingredients of DBD, exerts antitumor effects by targeting Snail family transcriptional repressor 2 (SNAI2). The addition of DBD or Formononetin inhibited the malignant activity and reduced the expression of SNAI2. However, this ability of Formononetin was reversed due to the overexpression of the SNAI2 gene. Formononetin inhibits the metastasis of TNBC by downregulating SNAI2. The outcomes offer a basis for the future clinical utilization of DBD and Formononetin in TNBC therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.