ArticleFrontiers in dental medicine2025
Gene and protein profiling of Dickkopf-3 and complement factor H in periodontitis and coronary artery disease.
Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to evaluate and compare demographic, periodontal, and cardiac parameters; Dickkopf-3 (DKK-3; rs11544817) and complement factor H (CFH; rs10737680) protein levels; and gene expression in patients with periodontitis with and without coronary artery disease (CAD) at baseline and following non-surgical periodontal therapy (NSPT). Methods: A total of 140 participants were divided into the following four groups ( Results: Group P + CAD had higher age, weight, and BMI, and lower socioeconomic status. Periodontal and cardiac parameters improved after NSPT. DKK-3 levels decreased and CFH levels increased post-treatment. Both proteins strongly correlated with gene expression, independent of confounders. The regression analysis confirmed their significant association with periodontitis and CAD risk. Conclusion: The study found elevated DKK-3 (rs11544817) and reduced CFH (rs10737680) protein levels and gene expression in patients with periodontitis and CAD, suggesting that these genes regulate their respective proteins.
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