Evidence map›Paper›PMID 41356204›Full record

ArticleTheranostics2026

A novel TM4SF4-targeting therapeutic antibody candidate with antitumor activity by blocking IGF1R and CD44 signaling and downregulating PD-L1 and B7-H4.

Rae-Kwon Kim, Chang-Kyu Heo, Mun Ju Choi, Yeon-Jee Kahm, Min Kyu Kim, Minyong Lee, Ji Yoon Lee, Hwangseo Park, Uhee Jung, Byung-Chul Shin and 5 more

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rae-Kwon KimDepartment of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute (KAERI), Daejeon 34057, Republic of Korea.
Chang-Kyu HeoInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Mun Ju ChoiDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
Yeon-Jee KahmDepartment of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute (KAERI), Daejeon 34057, Republic of Korea.
Min Kyu KimDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
Minyong LeeDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
Ji Yoon LeeDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
Hwangseo ParkDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
Uhee JungDepartment of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute (KAERI), Daejeon 34057, Republic of Korea.
Byung-Chul ShinDepartment of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute (KAERI), Daejeon 34057, Republic of Korea.
Bum-Jin KimAlgok Bio Inc. 320 120th Ave. NE #208 Bellevue, WA 98005, USA.
Sung-Chul KimAlgok Bio Inc. 320 120th Ave. NE #208 Bellevue, WA 98005, USA.
Eun-Wie ChoInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Chun Jeih RyuDepartment of Integrative Bioscience and Biotechnology, Institute of Bioscience, Institute of anticancer medicine development, Sejong University, Seoul 05006, Republic of Korea.
In-Gyu KimDepartment of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute (KAERI), Daejeon 34057, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalB7-H1 AntigenCarcinoma, Non-Small-Cell LungHyaluronan ReceptorsLung NeoplasmsReceptor, IGF Type 1V-Set Domain-Containing T-Cell Activation Inhibitor 1AnimalsCell Line, TumorDown-RegulationEpithelial-Mesenchymal TransitionFemaleHumansMiceMice, Inbred BALB CSignal TransductionAntibodies, MonoclonalB7-H1 AntigenCD274 protein, humanCD44 protein, humanHyaluronan ReceptorsIGF1R protein, humanReceptor, IGF Type 1V-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, humanEMT-associated stemnesshumanized antibody (Hz2B7-1.2)monoclonal antibody (2B7)signaling blockingTM4SF4

Identifiers

PMID41356204
PMCPMC12680531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.