ArticleFrontiers in surgery2025
Clinical efficacy evaluation of pedicled vascularized iliac bone graft transfer for osteonecrosis of the femoral head: a retrospective study with DCE-MRI/CTP analysis.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the clinical efficacy of pedicled vascularized iliac bone graft transfer (PVIBGT) in treating osteonecrosis of the femoral head (ONFH) at Association Research Circulation Osseous (ARCO) stages II-IIIB, to assess postoperative revascularization using standardized dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and CT perfusion imaging (CTP), and to identify independent predictors of surgical success through multivariate analysis. Methods: A retrospective analysis was conducted on 50 patients (51 hips) with ARCO stage II-IIIB ONFH (aged 18-48 years) who underwent PVIBGT between March 2021 and November 2024. Functional outcomes were assessed using Harris score. Radiographic evaluations (x-ray, CT) were used to assess bone graft integration and femoral head morphology. DCE-MRI parameters (IAUGC, CER, MaxSlope, Ktrans, Kep, Ve) and postoperative CTP indices (BF, BV, MTT) were used to quantify perfusion and microcirculatory status. Multivariate binary logistic regression including ARCO stage, etiology, age, sex, disease duration, and graft dimensions (length, diameter) was performed to identify independent predictors of hip-preservation success. Analyses were conducted using SPSS 26.0. Results: The mean follow-up duration was 15.1 months. Harris score improved significantly from a preoperative value of 62.39 ± 6.73 (median = 64.00, interquartile range = 10.00) to a postoperative value of 81.88 ± 10.20 (median = 85.00, interquartile range = 9.00) ( Conclusion: PVIBGT effectively improves hip function and delays femoral head collapse in ARCO II-IIIB ONFH. Combined DCE-MRI and CTP provide objective imaging evidence for postoperative revascularization assessment. No single factor independently predicted success, possibly due to limited sample size and subgroup heterogeneity. Larger, prospective multicenter studies with standardized imaging protocols and extended follow-up are warranted to confirm these findings.
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