ArticleWorld journal of clinical cases2025
Squamous cell carcinoma of unknown primary in the pelvis after complete remission following chemoradiotherapy: A case report.
Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPelvic squamous cell carcinoma of unknown primary (CUP) is extremely rare, accounting for less than one percent of all CUP cases, and its infrequency has limited the development of standardized diagnostic and treatment guidelines. CASE SUMMARY: A 77-year-old female with a history of resected lung adenocarcinoma presented with worsening constipation. Imaging revealed a 2.5 cm mass adjacent to the right levator ani muscle. Biopsy confirmed poorly differentiated squamous cell carcinoma, positive for pancytokeratin and p40, and negative for p16, cytokeratin 7, cytokeratin 20, and neuroendocrine markers. No primary lesion was identified despite extensive evaluation. She underwent five cycles of 5-fluorouracil (1000 mg/m
conclusionThis case highlights the potential role of chemoradiotherapy in managing pelvic squamous cell CUP, achieving durable remission in selected patients.
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