ArticleFrontiers in cellular and infection microbiology2025
Hospital-associated MRSA genotypes causing complicated community-onset skin and musculoskeletal infections.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Transmission and Evolution of Antibiotic Resistance Genes and Antibiotic-Resistant Bacteria in Animals, Food, Humans and the Environment.Microorganisms · 2026Review
- Bacterial pathogen spectrum and antimicrobial resistance in positive pus cultures from hospitalized patients at a maternal and child healthcare specialty hospital in Shenzhen, China, 2021-2025.Frontiers in cellular and infection microbiology · 2026Article
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6 authors.
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Abstract
Objectives: To assess clinical and epidemiological characteristics, and phenotypic and genomic risk factors associated with severity and death in complicated community-onset skin, soft tissue, and musculoskeletal infections (cSSTMIs) caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Patients with cSSTMIs were investigated between June 2022 to January 2024 and followed for one month after hospital discharge. Tissue samples were obtained through biopsy, punch, or fluid aspiration. All MRSA isolates underwent genomic sequencing. Factors associated with poor outcomes were analyzed using multivariate regression analysis, complemented by penalized regression (LASSO) with stratified cross-validation and sensitivity analyses to mitigate the risk of overestimation given the limited MRSA sample size. Results: A total of 118 patients were studied, 60.2% male, with a mean age of 41.1 years (± SD 26.1). Recurrence and death occurred in 13.5% and 7.6% of cases, respectively. Diagnostic yielded 145 microorganisms, 61.4% were Conclusions: High rates of antimicrobial resistance were observed in cSSTMIs, suggesting the need for empirical coverage, particularly in deep infections that were significantly associated with adverse outcomes.
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