Evidence map›Paper›PMID 41355951›Full record

ArticleTheranostics2026

A temporally functional composite hydrogel scaffold for cranial defect repair via sequential modulation of angiogenesis and osteogenesis.

Zongqiang Lv, Bo Sun, Rong Li, Bowen Zhao, Hongxiang Wang, Ning Luo, Xin Ding, Xuan Tang, Chunlin Wang, Long Bai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zongqiang LvDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Bo SunDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Rong LiDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Bowen ZhaoOrganoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Hongxiang WangDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Ning LuoDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Xin DingDepartment of Neurosurgery, No.901 Hospital of Joint Logistics Support Force of PLA, Hefei, 230031, Anhui, China.
Xuan TangOrganoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Chunlin WangDepartment of Neurosurgery, No.901 Hospital of Joint Logistics Support Force of PLA, Hefei, 230031, Anhui, China.
Long BaiOrganoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan SuOrganoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Juxiang ChenDepartment of Neurosurgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of large cranial defects remains a major clinical challenge, as conventional materials primarily act as inert fillers and fail to meet the complex biological requirements of cranial bone regeneration. In particular, they lack the ability to temporally coordinate angiogenesis and osteogenesis. This study aimed to develop a temporally functional composite scaffold to dynamically modulate the regenerative microenvironment and promote sequential vascularized bone regeneration.

Indexed as

HydrogelsNeovascularization, PhysiologicOsteogenesisSkullTissue ScaffoldsAngiogenesisAnimalsBenzofuransBone RegenerationCell DifferentiationDepsidesFibroinsHumansHuman Umbilical Vein Endothelial CellsMaleMesenchymal Stem CellsBenzofuransDepsidesFibroinsHydrogelssalvianolic acid Bcranial defectmineralized hydrogel microspheresalvianolic acid Bsilk fibroin hydrogeltemporal regulation

Identifiers

PMID41355951
PMCPMC12679569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.