Evidence map›Paper›PMID 41355947›Full record

ArticleJournal of electrical bioimpedance2025

Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study.

Callie L Unrein, David D Church, Arny A Ferrando, Robert R Wolfe, Katie R Hirsch

Abstract read
In one paragraph

Article in Journal of electrical bioimpedance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Callie L UnreinDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
David D ChurchCenter for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Arny A FerrandoCenter for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Robert R WolfeCenter for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Katie R HirschDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Age-related anabolic resistance can lead to reduced muscle mass but can be costly and timely to diagnose. Multi-frequency bioelectrical impedance analysis could potentially be used as a non-invasive tool for the assessment of anabolic resistance as changes in frequency-dependent impedance values may reflect fluid shifts occurring with nutrient uptake. This exploratory pilot study evaluated the effects of acute essential amino acid (EAA) intake on raw bioimpedance and fluid shifts in healthy young adults (YA, n=5) and older adults (OA, n=7). Methods: Participants completed a five-hour protocol with multifrequency bioelectrical impedance analysis (MF-BIA) at baseline and every 30 minutes post-consumption of a 10 g EAA beverage. Whole-body and segmental values for impedance (Z), resistance (R), reactance (Xc), phase angle (PhA), and body water compartments were assessed. Results: YA demonstrated significantly higher Z, R, Xc, and PhA values compared to OA (p<0.05), particularly in the leg segments and at 50 kHz. Time effects revealed declines in R (p=0.013) and Xc (p=0.002) following EAA ingestion, consistent with postprandial fluid shifts. Fluid analysis showed significant group differences only for ECW/ICW ratio (p=0.001-0.004) with OA > YA and increases in TBW, ICW, and ECW over time. Conclusion: Raw bioimpedance values distinguished between age groups and reflected acute responses to nutrient intake. These findings suggest MF-BIA may be sensitive to short-term physiological changes and, with further validation, could support assessments of muscle quality and nutritional responsiveness.

Indexed as

Bioimpedancebody wateressential amino acid

Identifiers

PMID41355947
PMCPMC12679906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.