SynthesisFrontiers in oral health2025
Association of torque teno virus in periodontitis: a systematic review, meta-analysis, and trial sequential analysis.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis, affecting 38.5% of adults globally with moderate-to-severe forms, represents a multifactorial inflammatory disease traditionally attributed to bacterial pathogens. Emerging evidence implicates viral cofactors, particularly Torque Teno virus (TTV), a ubiquitous anellovirus with 30%-95% prevalence in healthy populations. Objective: To evaluate TTV prevalence in periodontitis patients vs. controls through systematic review and meta-analysis. Methods: Following PRISMA guidelines, we searched multiple databases (2000-2024) for observational studies reporting TTV detection in oral samples using molecular techniques. Random-effects meta-analysis calculated pooled relative risk (RR) with 95% confidence intervals. Trial Sequential Analysis assessed evidence sufficiency. Results: Four studies encompassed 583 participants (300 periodontitis, 283 controls). Meta-analysis revealed significant TTV-periodontitis association (RR = 1.67; 95%CI: 1.28-2.17; Conclusion: Despite consistent TTV-periodontitis association across studies, evidence remains insufficient for definitive conclusions. Larger prospective investigations using standardized diagnostic criteria are essential to establish causality and clinical significance. Systematic Review Registration: PROSPERO CRD420251127439.
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