ArticleWorld journal of clinical oncology2025
Clinical outcomes of early-stage breast cancer in Morocco: A cohort of 400 women.
Article in World journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOutcomes of early breast cancer in African women are currently not well defined.
aimTo analyze survival outcomes and prognostic factors in Moroccan women with operable breast cancer treated with multimodal therapies.
methodsWe retrospectively analyzed the data of a large cohort of 400 patients diagnosed with nonmetastatic breast cancer who completed surgery, chemotherapy, and radiotherapy at the National Institute of Oncology in Rabat, from January 2001 to December 2003.
resultsThe mean age at diagnosis was 45 years (range: 22-91 years). Surgery was performed in all cases: Mastectomy in 86% and breast-conserving surgery in 14%. Most tumors (> 87%) were classified as pathologic T2 stage or higher, and axillary lymph nodes were involved in 75.5% of cases. Ninety-five percent of patients completed six cycles of adjuvant chemotherapy, and all received radiotherapy. At a median follow-up of 74.5 months, the 5-year overall survival (OS) was 82.1% [95% confidence interval (CI): 78.1-86.3], and the 5-year disease-free survival was 78.1% (95%CI: 73.8-82.6). In univariate analysis, negative nodal status [pN-
conclusionMoroccan women with early breast cancer exhibited more aggressive disease compared to women in high-income countries. AJCC stage III was the strongest predictor of poorer OS, followed by chemotherapy regimen (CMF
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