Evidence map›Paper›PMID 41355885›Full record

ArticleBurns & trauma2025

Multiple dynamic crosslinked multifunctional hydrogels with glucose/pH dual-responsive adipose-derived stem cells-exosomes-releasing for diabetic wound healing.

Yue Zhang, Meng Li, Shijie Song, Fenghui Hei, Shaoyang Ma, Jiao Cao, Baolin Guo, Dahai Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue ZhangDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.ORCID https://orcid.org/0009-0001-2552-7146
Meng LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Hedi Road, Chang'an District, Xi'an, Shaanxi 710049, China.
Shijie SongDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Fenghui HeiDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Shaoyang MaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Hedi Road, Chang'an District, Xi'an, Shaanxi 710049, China.
Jiao CaoKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Hedi Road, Chang'an District, Xi'an, Shaanxi 710049, China.
Baolin GuoKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, and State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Hedi Road, Chang'an District, Xi'an, Shaanxi 710049, China.
Dahai HuDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.ORCID https://orcid.org/0000-0002-3640-6729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic wounds feature a high-glucose and acidic microenvironment that impairs macrophage polarization and healing. Adipose-derived stem cell-derived exosomes (ADSC-exos) show therapeutic potential but suffer from rapid clearance. This study aimed to develop a smart hydrogel for glucose/pH-responsive ADSC-exos release. Methods: A dual-responsive hydrogel (HAP/OCS/PEG/Ag-E) was fabricated via dynamic triple cross-linking. Characterization included rheometry, mechanical tests, and microscopy. In vitro macrophage polarization was assessed via flow cytometry and Western blot. A diabetic mouse wound model evaluated healing rates, histology, angiogenesis, and inflammation. Proteomics and pathway inhibition studies explored mechanisms. Statistical analysis used t-tests and ANOVA. Results: The hydrogel exhibited excellent self-healing, adhesion, and controlled ADSC-exos release under high-glucose/acidic conditions. It promoted M2 macrophage polarization, reduced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and accelerated wound healing with enhanced angiogenesis and collagen deposition. Mechanistically, the hydrogel suppressed the Notch/NF-κB/NLRP3 signaling pathway. Conclusion: The smart hydrogel facilitates diabetic wound healing through microenvironment-responsive ADSC-exos release and Notch/NF-κB/NLRP3 pathway inhibition, offering a promising strategy for chronic wound treatment.

Indexed as

ADSC-exosChronic diabetic woundGlucose/pH dual responsive hydrogelsInflammationMacrophage

Identifiers

PMID41355885
PMCPMC12681253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.