ArticleInternational journal of general medicine2025
Diaphragm Contraction Pressure Index: A New Forecasting Indicator for Weaning from Mechanical Ventilation.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Purpose: Failure to wean from mechanical ventilation can lead to prolonged hospital stays, increased incidence of ventilator-associated pneumonia, and higher mortality rates. This study aimed to explore the effectiveness of the diaphragm contraction pressure index (DCPI) in predicting weaning outcomes in patients undergoing mechanical ventilation, providing a scientific basis for successful weaning in clinical practice. Patients and Methods: This prospective observational study included 286 individuals in the derivation cohort and 104 patients in the validation cohort, all of whom completed the spontaneous breathing trial (SBT). During SBT, ultrasound was used to quantify the right hemidiaphragm excursion (DE), diaphragm thickness (DTF) after inspiration and expiration, and DCPI. MIP values were gathered from the mechanical ventilator when the patients breathed peacefully. The derivation cohort determined the cut-off value of DCPI and compared these ultrasound diaphragm parameters. The validation cohort contributes to verifying the accuracy of DCPI. Results: The weaning success group's DCPI in the derivation cohort was significantly higher than that of the weaning failure group (36.67% ± 7.02% vs 24.03% ± 5.78%, Conclusion: Compared with DTF, DE, and MIP, DCPI dramatically improves the accuracy of predicting successful weaning. Trial Registration: No. ChiCTR2100052470, Registered 28 October 2021.
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