ArticleWorld journal of orthopedics2025
Correlation of magnetic resonance imaging biomarkers (tissue bridges) with neurological recovery following traumatic spinal cord injury.
Article in World journal of orthopedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Magnetic resonance imaging tissue bridges: An emerging biomarker for prognostication in traumatic spinal cord injury.World journal of orthopedics · 2026Article
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5 authors.
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Abstract
backgroundSpinal cord injury (SCI) imposes enduring physical impairments and substantial socio-economic burdens. These injuries are either traumatic incidents or ischemic but exhibit comparable clinical recoveries. This suggests shared underlying neurodegenerative mechanisms, such as neuronal cell death, demyelination, and axonal degeneration, regardless of aetiology.
aimTo investigate the relationship between the magnetic resonance imaging (MRI) biomarkers (tissue bridges) and clinical outcome in acute traumatic SCI.
methodsIn this prospective study adult patients with acute SCI who were examined clinically and radiologically within first 48 hours and subsequently at intervals were included. Clinical assessment included sensory score, motor score and zone of partial preservation. Radiological scores included measurement kyphotic deformities - sagittal index, regional kyphosis, gardener segmental kyphotic deformity. MRI on 3 Tesla machine was done to evaluate quantitative & qualitative parameters, and tissue bridges at one and 6 months.
resultsThere were 47 patients with a mean age of 40.43 ± 10.73 years and male/female ratio of 34:13. There was a significant (
conclusionThe MRI imaging biomarkers in SCI patients demonstrated substantial improvement over time. There was a negative correlation between neurological recovery, MSCC, maximum canal compromise, and lesion dimensions (lesion length, lesion width, and lesion area). Higher canal compromise and lesion dimensions were associated with a poorer outcome. The evaluation of the midsagittal tissue bridge (including the ventral tissue bridge, dorsal tissue bridge, total width of the tissue bridge, and tissue bridge ratios) at 1 and 6 months showed a positive correlation with the neurological recovery.
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