ReviewJournal of medicinal chemistry2025
Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?
Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Clean Synthesis of N-4-Alkylamino-7-chloroquinoline Cyclic Imides: Influence of Lipophilicity on Antibacterial and Ecotoxicological Properties.Chemistry & biodiversity · 2026Article
- Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents.Organic process research & development · 2026Article
- "Green-path": planting seeds for environmental sustainability in diagnostic and research surgical pathology.Virchows Archiv : an international journal of pathology · 2026Review
- Improvement of CsMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solvent selection plays a critical role in promoting synthetic chemistry reactions. Metrics from the ACS-GCIPR have led to an estimate that solvents utilized contribute 80-90% of the waste streams of pharmaceutical manufacturing processes. The medicinal chemistry team of the ACS-GCIPR has performed a systematic study of the most common transformations (over 400k reactions) utilized in the drug discovery phase examining the solvents in which these reactions are performed. Specifically, we have focused on the use of several solvents that are undesirable based on their hazardous nature and/or known adverse effects on human health. The data have shown that in over 40% of cases, the reactions profiled are conducted in what is an undesirable solvent with the use of methylene chloride and
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.