Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07526948 (Vaginal Estradiol Versus Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms, Dysbiosis and Markers of Latency Reversal in Menopausal Women Living With HIV), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07526948 phase4not yet recruitingnot on this map
Vaginal Estradiol Versus Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms, Dysbiosis and Markers of Latency Reversal in Menopausal Women Living With HIV
TypeinterventionalSponsorAlbert Einstein College of MedicineRan2026 to 2029Enrolled62ConditionsMenopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus)ArmsVaginal estradiol tablets, Vaginal moisturizer
3 · Its place in the literature
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Kerry MurphyDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-5272-333X
Matthew GromischDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0009-0006-2701-1115
John ConnollyDepartment of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0009-0002-8917-2353
Tao WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Jessica McWaltersDepartment of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Jessica AtrioDepartment of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-3505-643X
Aakash Mahant MahantDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-0530-122X
Shweta GeraDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Agnes ColantaDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Antonio CajigasDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Libusha KellyDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Hayley EstrellaDrexel University College of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0009-0001-8045-4103
Deborah GustafsonState University of New York Downstate, Health Sciences University, Brooklyn, New York, USA.ORCID 0000-0001-9556-8560
Howard MinkoffState University of New York Downstate, Health Sciences University, Brooklyn, New York, USA.
Kathryn AnastosDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Marla J KellerDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-0417-4000
Betsy C HeroldDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-9974-0786
Funding
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Vilma Gabbay · 2017 to 2026
$28.3M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
Einstein-Montefiore Clinical and Translational Science Award HubUM1TR004400 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jessica Kahn, Mimi Y Kim · 2023 to 2026
$17.3M
Mechanisms Underlying the HIV-HSV-2 SyndemicR01AI134367 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Betsy C. Herold · 2018 to 2026
$4.9M
Impact of the vaginal microbiome on topical HIV pre-exposure prophylaxis (PrEP)R01HD098977 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HEROLD, BETSY C. · 2019 to 2023
$2.6M
The impact of HIV on accelerated aging in the female genital tract: a pilot trial of topical estradiol to improve the vaginal microbiome and symptoms of vaginal atrophy in menopausal women with HIVK23AG062400 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MURPHY, KERRY JEANNE · 2020 to 2023
$791k
an Einstein Resnick Center Emerging Scholars in Aging AwardEinstein-Rockefeller-CUNY Center for AIDS ResearchEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentIrma L. and Abram S. Croll Charitable TrustNational Aging InstituteNational Institute for Allergy and Infectious DiseasesNCATS NIH HHSNCATS NIH HHS UM1 TR004400NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146204NIAID NIH HHS P30 AI124414NIAID NIH HHS R01 AI134367NIA NIH HHS K23 AG062400NICHD NIH HHS R01 HD098977NIH HHS K23 AG062400NIH HHS R01 AI134367NIH HHS R01 HD098977NIH HHS UM1 TR004400
6 · The paper itself
Abstract
backgroundWomen with human immunodeficiency virus (HIV, WWH) experience early onset menopause and symptoms may impact antiretroviral therapy (ART) adherence. Vaginal estradiol is safe and effective for treatment of the genitourinary syndrome of menopause (GSM) but has not been studied in WWH. The study objective was to test whether vaginal estradiol would improve GSM symptoms in menopausal WWH.
methodsMenopausal WWH were randomized 1:1 to 12 weeks of open-label vaginal estradiol (n = 25) versus no treatment (n = 26). Participants had at least 1 GSM vulvovaginal symptom in the month prior (dryness, itching, irritation, soreness, or dyspareunia) and clinical atrophy. The primary outcome was difference in mean symptom severity (scale 0-3) defined by the composite vaginal symptom index (VSI) between baseline and week 12. Changes in severity of participants' most bothersome symptom (MBS), vaginal maturation index (VMI), vaginal microbiome, and mucosal immune mediators were assessed. Results were compared by paired t test or Wilcoxon signed rank tests; a mixed effect model examined differences in VSI improvement between groups.
resultsMean age was 59 years, 78% self-reported as Black, and all were on ART. Both groups had significant reductions in VSI, however the magnitude was significantly greater in the estradiol group (P < .0001). Estradiol and younger age were associated with VSI improvement. VMI and MBS improved significantly only in the estradiol group. There were no significant changes in the microbiome or mucosal mediators.
conclusionsThe favorable response to estradiol suggests that treatment perhaps initiated earlier may be beneficial for GSM in WWH and should be studied in larger clinical trials.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Impact of Vaginal Estradiol on the Genitourinary Syndrome of Menopause, Vaginal Microbiome and Mucosal Immune Mediators in Women With HIV. · full record | OpenQuestion