ArticleDevelopment, growth & differentiation2026
BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.
Article in Development, growth & differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.Development, growth & differentiation · 2026Article
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12 authors.
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Abstract
Programmed cell death during embryonic development plays a vital role in shaping limb morphology in amniotes. BMP (bone morphogenetic protein) signaling has been shown to be essential for inducing interdigital cell death, but its relationship with reactive oxygen species (ROS) production, another driver of this process, remains unclear. Here, we show that BMP signaling modulates ROS production, which is required for subsequent cell death in the interdigital regions of chicken hindlimbs. Through transcriptome analyses, we identify the candidate genes encoding molecular machinery potentially involved in ROS production in response to changes in BMP signaling. Our findings suggest that BMP signaling may influence the redox balance by upregulating the genes encoding ROS-generating enzymes such as Nox2 and Nox4 (components of NADPH oxidase), and downregulating the ROS-scavenging enzyme Sod1. Pharmacological inhibition of NADPH oxidase reduces ROS levels and cell death, indicating that ROS production in the chicken interdigital cell regions is at least partially NADPH oxidase-dependent. Together, these results support a model in which BMP signaling is required for the regulation of programmed cell death, at least in part by modulating redox homeostasis.
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