ArticleJournal of anatomy2026
Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model.
Article in Journal of anatomy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects hyaline cartilage, except in the case of the temporomandibular joint (TMJ), which is covered by fibrocartilage. This study compared the progression of RA in these two types of cartilage by examining the TMJ and knee joints of rats in both the acute and chronic phases of the disease. Forty-eight male Wistar rats were divided into groups: Control (animals without RA in the TMJ or knee), RA-24h, and RA-7d (animals with RA in the TMJ or knee, euthanized 24 h or 7 days after the last intra-articular injection, respectively). The rats were sensitized with subcutaneous injections containing complete/incomplete Freund's adjuvant and methylated bovine serum albumin (mBSA), followed by three intra-articular mBSA injections (one per week) into either the TMJ or knee. Euthanasia was performed 24 h (acute phase) or 7 days (chronic phase) after the third injection. The following parameters were assessed: nociceptive thresholds, cellular influx in synovial fluid, histopathology, immunohistochemistry for metalloproteinase-9 (MMP-9), and birefringence of collagen fibers in articular cartilage. A significant reduction in the nociceptive threshold was observed in arthritic animals in both joints compared to the control groups. Additionally, a significant increase in cellular influx in the synovial membrane was noted in both joints after the third mBSA injection, as well as in the knee after 7 days. Histopathological analysis revealed reduced metachromasia, increased MMP-9 immunoexpression, and higher levels of type III collagen in the articular cartilage compared to the respective controls (p < 0.05). The nociceptive response was similar in both joints during the acute and chronic phases of RA. However, evidence of articular repair was observed in the TMJ, accompanied by a sustained reduction in the nociceptive threshold, suggesting central sensitization without ongoing peripheral damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.