Evidence map›Paper›PMID 41355244›Full record

ArticleActa crystallographica. Section F, Structural biology communications2026

Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound.

Jacqueline Vitali, Jay C Nix, Haley E Newman, Michael J Colaneri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacqueline VitaliDepartment of Physics, Cleveland State University, Cleveland, Ohio, USA.ORCID 0000-0003-3029-8496
Jay C NixMolecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California, USA.ORCID 0000-0002-4041-4975
Haley E NewmanDepartment of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
Michael J ColaneriDepartment of Chemistry and Physics, State University of New York at Old Westbury, Old Westbury, New York, USA.ORCID 0000-0001-6462-7919

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Cleveland State University Undergraduate Research AwardCleveland State University Undergraduate Student Research AwardsNIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM124169-01NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Here, we report the X-ray structural analysis of dihydroorotase from Methanococcus jannaschii co-crystallized with dihydroorotate at pH 6.5. The crystals are isomorphous with the crystals of the apoenzyme, with space group P3

Indexed as

Archaeal ProteinsDihydroorotaseMethanocaldococcusAmino Acid SequenceAspartic AcidCatalytic DomainCloning, MolecularCrystallizationCrystallography, X-RayEscherichia coliGene ExpressionModels, MolecularProtein BindingProtein ConformationRecombinant ProteinsSubstrate SpecificityArchaeal ProteinsAspartic AcidDihydroorotaseRecombinant Proteinsdihydroorotaseflexible loopMethanococcus jannaschiipyrimidine biosynthesis

Identifiers

PMID41355244
PMCPMC12809426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.