Evidence map›Paper›PMID 41355213›Full record

ArticleMolecular oral microbiology2026

Porphyromonas gingivalis-Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein-1 Canonical Signaling.

Chiaki Yamada, Gang Peng, James A Johnson, Amilia Nusbaum, Natasha Sanz, Hawra AlQallaf, Frank Nichols, Alexandru Movila

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiaki YamadaDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Gang PengIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.
James A JohnsonDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Amilia NusbaumDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Natasha SanzDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Hawra AlQallafDepartment of Periodontology, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Frank NicholsDepartment of Periodontology, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA.ORCID 0000-0001-6800-1112
Alexandru MovilaDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, Indiana, USA.ORCID 0000-0001-9827-7347

Funding

Impact of Acid Ceramidase Activity on MIF-mediated migration of circulating osteoclast precursors to periodontal bone lesions in relation to agingR01AG064003 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2019 to 2022
$1.8M
Hevolution Foundation HF-GRO-23-1199172-46NIA NIH HHS R01AG064003NIH HHS 1RF1AG077826NIH HHS R01 ES029835GWU.S. Department of Veterans Affairs I21BX006307
6 · The paper itself

Abstract

Periodontal bacterial pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules are periodontal bacterium Porphyromonas gingivalis-derived virulence lipids, for example, phosphoglycerol dihydroceramide (PGDHC) and lipopolysaccharide (LPS Pg), and the host non-histone alarmin high mobility group box protein-1 (HMGB1), respectively. Although it was reported that extracellularly released HMGB1 is critical for the promotion of sepsis inflammation in response to non-periodontal bacterial LPS, our understanding of the crosstalk between HMGB1 and P. gingivalis-derived virulence lipids remains limited. Therefore, we used Hmgb1

Indexed as

HMGB1 ProteinOsteoclastsOsteogenesisPorphyromonas gingivalisAlveolar Bone LossAnimalsLipopolysaccharidesMiceMice, Inbred C57BLRANK LigandSignal TransductionVirulenceHMGB1 ProteinHMGB1 protein, mouseLipopolysaccharidesRANK Ligandguanylate‐binding proteinshigh mobility group box protein 1matrix metalloproteasesosteoclastogenesisPorphyromonas gingivalisvirulent lipids

Identifiers

PMID41355213
PMCPMC12964516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.