Evidence map›Paper›PMID 41355185›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Brain glucose extraction is fixed at 10% despite twofold variability in resting cerebral blood flow in healthy humans.

Jennifer S Duffy, Hannah G Caldwell, Ryan L Hoiland, Connor A Howe, Kurt J Smith, Anthony R Bain, David B MacLeod, Philip N Ainslie, Travis D Gibbons

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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Brain glucose extraction is fixed at 10% despite twofold variability inJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jennifer S DuffySchool of Physical Education, Sport & Exercise Sciences, University of Otago, Dunedin, New Zealand.ORCID 0009-0003-1350-7353
Hannah G CaldwellCentre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Ryan L HoilandCentre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, BC, Canada.
Connor A HoweCentre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Kurt J SmithCerebrovascular Health Exercise and Environmental Research Sciences Laboratory, School of Exercise Science, Physical and Health Education, Faculty of Education, University of Victoria, Victoria, BC, Canada.
Anthony R BainDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, ON, Canada.
David B MacLeodDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Philip N AinslieCentre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Travis D GibbonsDepartment of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA.ORCID 0000-0003-3893-9948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the resting, non-stimulated brain, metabolic demands are met exclusively by the delivery and extraction of glucose and oxygen at an ~6:1 ratio. Amongst healthy people at rest, there is marked variability in resting global cerebral blood flow (CBF) yet remarkably stable concentrations of circulating glucose and oxygen. Thus, we would expect interindividual variability in resting CBF to be inversely related to oxygen and glucose extraction, maintaining oxidative glucose metabolism. Herein, we investigated the fundamental relationship between CBF and substrate extraction in 75 healthy adults (27.3 ± 4.8 years) with resting measures of CBF and cross-brain concentrations of oxygen and glucose. We observed that the marked interindividual variability in CBF (<500 to >1200 mL/min) is inversely related to oxygen extraction (

Indexed as

aerobic glycolysisarteriovenouscerebral blood flowCerebral metabolismglucose extractionoxygen extraction

Identifiers

PMID41355185
PMCPMC12685695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.