Evidence map›Paper›PMID 41355063›Full record

ArticleAdvanced biology2026

Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis.

Daniel R Pfau, Monica A Rionda, Evelyn Cho, Jamison G Clark, Robin E Kruger, Ruth K Chan-Sui, Vasantha Padmanabhan, Molly B Moravek, Ariella Shikanov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Daniel R PfauObstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4510-647X
Monica A RiondaBiomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4761-4179
Evelyn ChoPediatric Endocrinology, University of Michigan, Ann Arbor, Michigan, USA.
Jamison G ClarkSchool of Social Work, University of Michigan, Ann Arbor, Michigan, USA.
Robin E KrugerObstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-2190-2455
Ruth K Chan-SuiObstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0000-9619-7116
Vasantha PadmanabhanObstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8443-7212
Molly B MoravekObstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-9972-4938
Ariella ShikanovObstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-0159-6419

Funding

Postdoc Stipend Supplement: Developmental Origins of Metabolic Disorders T32T32DK071212 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON, Kanakadurga Singer · 2005 to 2026
$5.4M
Reproductive Consequences of Steroid Hormone AdministrationR01HD098233 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAVEK, MOLLY BENNETTE · 2019 to 2023
$2.6M
NICHD NIH HHS R01 HD098233NIDDK NIH HHS T32 DK071212NIH HHS R01 HD098233NIH HHS T32DK071212
6 · The paper itself

Abstract

Gender-affirming hormone therapy (GAHT) relies on exogenous hormones to produce hormonal milieus that achieve and/or maintain embodiment goals. Another potential route to these endpoints is transplantation of novel steroidogenic tissue. To develop a pre-clinical model, we asked whether different-sex gonad transplants can be functionally integrated into the adult mouse hypothalamic-pituitary-gonadal (HPG) axis. Adult male and female mice are gonadectomized and implanted with gonads from genetically matched but different-sex pups. Controls received gonads from same-sex pups. Temporal changes to gonadotropin and steroid hormone levels reveal the decoupling of the HPG following gonadectomy and gonad-dependent levels after transplanting donor gonads. After six weeks, histological structures in transplanted gonads are consistent with expected steroidogenesis and gametogenesis. Interestingly, pituitary, ARC, and AVPV mRNA showed gonad- and sex-dependent expression patterns. Future work with this technique could lead to translation to gender affirming care and explorations of gonad-dependent sex differences in biomedical and basic research.

Indexed as

GonadsHypothalamo-Hypophyseal SystemAnimalsFemaleHypothalamic-Pituitary-Gonadal AxisMaleMiceMice, Inbred C57BLgender‐affirming hormone therapyovarysex differencetestistransgender

Identifiers

PMID41355063
PMCPMC12798698

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.