ArticleEuropean journal of medical research2025
The impact of operative hysteroscopy on pregnancy outcomes in patients with suspected uterine cavity lesions prior to the first frozen-thawed embryo transfer: a retrospective propensity-score matching cohort study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundHysteroscopy is a common procedure in assisted reproductive technology (ART) and serves as the gold standard for diagnosing and treating uterine cavity lesions. However, there is currently a lack of research on the impact of operative hysteroscopy prior to the first frozen-thawed embryo transfer (FET) on subsequent pregnancy outcomes in patients with suspected uterine cavity lesions. This study aimed to investigate whether performing operative hysteroscopy before the first FET improved pregnancy outcomes within this patient population.
methodsA retrospective propensity-score matching (PSM) Cohort Study. A cohort comprised of 879 patients (879 cycles) who underwent their first FET at the Reproductive Medicine Center of the Second Affiliated Hospital of the Naval Medical University between July 1, 2021, and May 31, 2024. The follow-up period extended until December 31, 2024. Participants were categorized into two groups: those with suspected uterine cavity lesions who underwent operative hysteroscopy (hysteroscopy group, 526 cycles), and those without suspected lesions who did not receive hysteroscopy (control group, 353 cycles). Compared the pregnancy outcomes between the two groups and performed binary logistic regression analysis to assess the impact of operative hysteroscopy on clinical pregnancy rate (CPR) and live birth rate (LPR).
resultsBoth before and after PSM, the hysteroscopy group exhibited higher CPR (pre-PSM: 68.06% vs. 53.54%; post-PSM: 65.03% vs. 54.90%, P < 0.05) and LBR (pre-PSM: 53.80% vs. 43.34%; post-PSM: 52.79% vs. 44.40%, P < 0.05) compared to the control group. Binary logistic regression analyses of all three models consistently demonstrated that operative hysteroscopy was significantly associated with improved clinical pregnancy and live birth rates. After adjusting for confounding factors, including age, body mass index, delivery mode, number of miscarriages, fertilization method, FET protocol, embryo attributes, number of embryos transferred, and endometrial thickness, operative hysteroscopy still increased CPR by 54.3% (OR 1.543, 95% CI 1.070-2.227) and LBR by 44.2% (OR 1.442, 95% CI 1.011-2.056).
conclusionsThis study confirmed that in patients with suspected uterine cavity lesions, performing hysteroscopic surgery before the first frozen-thawed embryo transfer can improve both CPR and LBR.
trial registrationThis is a retrospective cohort study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.