Evidence map›Paper›PMID 41354953›Full record

ArticleTransgenic research2025

Functional divergence of zebrafish keap1 paralogs revealed by CRISPR/Cas9-mediated gene editing: a specialized role for keap1b in inflammation.

Vu Thanh Nguyen, Bui Thi Thu Van, Tran Ngoc Uyen, Nguyen Xuan Tong, Thanh Luu Pham, Nguyen Hoang Thuy Vy, Dinh Thi Thuy, Nguyen Phuong Thuy, Makoto Kobayashi

Abstract read
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In one paragraph

Article in Transgenic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vu Thanh Nguyen *Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam. nthanhvu.shtp@tphcm.gov.vn.
Bui Thi Thu Van *Department of Biotechnology, HUTECH Institute of Applied Sciences, HUTECH University, Ho Chi Minh City, Vietnam.
Tran Ngoc UyenDepartment of Biotechnology, HUTECH Institute of Applied Sciences, HUTECH University, Ho Chi Minh City, Vietnam.
Nguyen Xuan TongInstitute of Environmental Science, Engineering and Management, Industrial University of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Thanh Luu PhamFaculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Nguyen Hoang Thuy VyBiotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Dinh Thi ThuyDepartment of Engineering and Technology, Van Hien University, Ho Chi Minh City, Vietnam.
Nguyen Phuong ThuySchool of Agriculture and Aquaculture, Tra Vinh University, Vinh Long, Vietnam.
Makoto KobayashiDepartment of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Funding

National Foundation for Science and Technology Development 108.06-2020.19
6 · The paper itself

Abstract

The Keap1/Nrf2 signaling pathway is a master regulator of cellular defense against oxidative and electrophilic stress. In teleosts like zebrafish (Danio rerio), whole-genome duplication resulted in two keap1 paralogs, keap1a and keap1b, whose functional specificities remain incompletely understood. This study investigates the divergent roles of these paralogs by comparing the responses of established keap1a and novel keap1b knockout larvae to distinct chemical stressors. By comparing the responses of keap1b

Indexed as

CRISPR-Cas SystemsInflammationZebrafishZebrafish ProteinsAnimalsCarrier ProteinsGene EditingKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oxidative StressSignal TransductionCarrier ProteinsKeap1a protein, zebrafishKelch-Like ECH-Associated Protein 1nfe2l2a protein, zebrafishNF-E2-Related Factor 2Zebrafish ProteinsCRISPR/Cas9Functional divergenceInflammationKeap1bOxidative stressZebrafish

Identifiers

PMID41354953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.