ArticleNature communications2025
DNA methylation of the endothelin receptor B makes blue fish yellow.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Color patterns as a model for connecting developmental mechanisms to phenotypic evolution.Nature communications · 2026Review
- Epigenetics in Captivity: Restoring Wild Phenotypes in Captive-Reared Salmonids.Evolutionary applications · 2026Article
- DNA methylation of the endothelin receptor B makes blue fish yellow.Nature communications · 2025Article
- Integrative Methylome and Transcriptome Analysis Reveals Epigenetic Regulation of Pigmentation in Oujiang Color Common Carp.International journal of molecular sciences · 2025Article
- Male-male competition affects color phenotype expression and color-dependent oxidative stress levels in a polymorphic cichlid fish.Ethology : formerly Zeitschrift fur Tierpsychologie · 2025Article
- DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism inAntioxidants (Basel, Switzerland) · 2025Article
- Sexual selection may support phenotypic plasticity in male coloration of an African cichlid fish.Proceedings. Biological sciences · 2024Article
- Background color matching affects sexual behavior, growth, and mortality rate in an African cichlid.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Animal pigmentation is essential for concealment and communication in nature. Though selection acts on the phenotypes of an organism, these traits are often resolved to genes that shape pigmentation in populations. In contrast, plasticity in coloration can occur within individuals in response to ambient environmental changes that act through integrative processes. It is well known that some animals often change color to match their visual ecology. The cichlid fish, Astatotilapia burtoni, can switch between robust blue and yellow body morphs in the lab and the wild. Different colors result from the positioning and density of chromatophores between different morphs and patterns. We show that A. burtoni switches from yellow to blue depending on its visual environment by downregulating endothelin receptor B (EdnRBa) mRNA via DNA hypermethylation at a single cytosine residue within its promoter. EdnRBa functions in yellow chromatophores to signal the aggregation of yellow pigments, making yellow less visible. Taken together, the regulation of EdnRBa through DNA methylation in yellow chromatophores contributes to pigmentation changes from blue to yellow morphs and their overall phenotypic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.