ArticleInternational journal of retina and vitreous2025
Intraocular inflammation following aflibercept 8 mg: real-world data from a multicentre retrospective observational study.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Real-world safety of aflibercept 8 mg in neovascular age-related macular degeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Prospective Real-World Outcomes After Switching to Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration with High Treatment Burden.Ophthalmology and therapy · 2026Article
- Lower Rates of Intraocular Inflammation with Aflibercept 8 mg Delivered via Pre-Filled Syringe Versus Vial.Ophthalmology and therapy · 2026Article
- Systemic and ocular complications related to intravitreal administration of anti-VEGF agents.Medical hypothesis, discovery & innovation ophthalmology journal · 2026Review
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7 authors.
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Abstract
backgroundReal-world data on intraocular inflammation (IOI) following aflibercept 8 mg is limited. We report on a cluster of 12 eyes with aflibercept 8 mg-associated IOI detected at three centres between July 2024 and June 2025.
methodPrimary outcome measures of the retrospective observational study were the classification of severity according to the SUN classification and the determination of the incidence of aflibercept 8 mg-associated IOIs. The inclusion criterion was on-label therapy in treatment-naive and patients switched to aflibercept 8 mg who developed sterile inflammation within 1 to 14 days after injection without a history of uveitis. Data was collected by means of medical history, clinical biomicroscopic examination, optical coherence tomography and fluorescein angiography. The incidence was calculated based on the number of injections performed at the three centres between July 2024 and March 2025.
resultsThe case series comprises 12 eyes from 10 patients (7 women, 3 men) with post-injection IOI after an average of 1.9 days (SD: 0.6); nAMD (80.0%) / DME (20.0%). IOI occurred on average after 2.3 injections (SD: 1.6), with 91.7% pretreated without IOI event (including aflibercept 2 mg (66.7%)). Anterior uveitis developed in 16.7%, intermediate uveitis in 66.7% and posterior uveitis in 16.7%. The incidence was 1.4% per aflibercept 8 mg injection (11 eyes out of 775 injections; 95% CI: 0.6–2.2%).
conclusionInitial real-world data indicate a slightly increased risk of IOIs with aflibercept 8 mg compared to the pivotal studies, some of which are fulminant and difficult to distinguish from endophthalmitis.
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