SynthesisBMC oral health2025
Therapeutic potential of dental mesenchymal stem cells versus mesenchymal stem cells from other sources: a systematic review of animal studies.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStem cell-based therapy, a crucial area of regenerative medicine, aims to enhance the body’s repair mechanisms by stimulating, modulating, and regulating endogenous stem cells or replenishing cell pools, thereby promoting tissue homeostasis and regeneration and offering promising treatments for numerous systemic diseases. This systematic review comprehensively summarizes animal studies investigating the efficacy of dental mesenchymal stem cells (DMSCs) in treating systemic diseases and promoting tissue regeneration compared to mesenchymal stem cells (MSCs) derived from other sources.
methodsPICO question was, “What is the difference in efficacy between dental-derived mesenchymal stem cells and mesenchymal stem cells from other sources when used for the treatment of systemic diseases and/or tissue regeneration?” A comprehensive search, up to October 2024, across PubMed, Embase, and Scopus was conducted using a defined search strategy to identify relevant studies. Controlled animal studies were included, and the risk of bias was assessed using the SYRCLE tool.
resultsThis systematic review included 29 studies published between 2008 and 2024, comparing the therapeutic efficacy of various dental-derived stem cells, including DPSCs (Dental Pulp Stem Cells), DPNCCs (Dental Pulp Neural Crest Cells), GMSCs (Gingival Mesenchymal Stem Cells), SHEDs (Stem Cells from Human Exfoliated Deciduous Teeth), and PDLSCs (Periodontal Ligament Stem Cells) with other stem cell sources in preclinical animal models. DMSCs demonstrated significant osteogenic potential, enhanced neuroprotection, angiogenesis, and robust immunomodulatory effects, showing superior performance compared to bone marrow mesenchymal stem cells (BMMSCs) and other sources in tissue repair, functional recovery, and inflammation modulation across multiple systems, including musculoskeletal, oral, ocular, neural, immune, dermal, metabolic, cardiovascular, and pulmonary. However, some studies reported similar or slightly better outcomes with other stem cell types, depending on the specific application or disease model.
conclusionDMSCs exhibit promising therapeutic potential, often outperforming traditional MSC sources such as bone marrow and adipose tissue in preclinical settings. Their accessibility through minimally invasive procedures and robust regenerative properties position them as a viable option for translational medicine. However, methodological heterogeneity and limited standardization across studies necessitate further rigorous research to validate these findings and optimize their clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.