Evidence map›Paper›PMID 41354887›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Cu(I)-N-Heterocyclic carbenes as potent inhibitors of SARS-CoV-2 replication.

Igor Andrade Santos, Josielle V Fontes, Gustavo C Rodrigues, Mariana Ortiz de Godoy, Glaucius Oliva, Rafael V C Guido, Andres Merits, Camilla Abbehausen, Mark Harris, Ana Carolina Gomes Jardim

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Igor Andrade SantosInstitute of Biomedical Sciences, Federal University of Uberlândia (UFU), Avenida Amazonas, 4C-Room 216, Umuarama, CEP: 38405-302, Brazil.
Josielle V FontesInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Gustavo C RodriguesInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Mariana Ortiz de GodoyInstituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
Glaucius OlivaInstituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
Rafael V C GuidoInstituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
Andres MeritsInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Camilla AbbehausenInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Mark HarrisSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. m.harris@leeds.ac.uk.
Ana Carolina Gomes JardimInstitute of Biomedical Sciences, Federal University of Uberlândia (UFU), Avenida Amazonas, 4C-Room 216, Umuarama, CEP: 38405-302, Brazil. jardim@ufu.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404668/2021-6Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01487-22Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/02618-0Medical Research Council MR/S001026/1
6 · The paper itself

Abstract

SARS-CoV-2 still poses as a threat to health systems despite the vaccination and the use of emergency repurposed drugs. Therefore, the development of novel anti-SARS-CoV-2 compounds is still needed. Organometallic copper(I)-N-heterocyclic carbenes [Cu(NHC)] are a class of metallodrugs that hold promise for drug development due to their variety of geometries, charges, and ligand design. Here we evaluated the activity of Cu(IPr)Cl, Cu(IMes)Cl, and [Cu(IMes)

Indexed as

Antiviral AgentsCoordination ComplexesCopperCOVID-19 Drug TreatmentHeterocyclic CompoundsMethaneOrganometallic CompoundsSARS-CoV-2Virus ReplicationA549 CellsCOVID-19HumansAntiviral AgentscarbeneCoordination ComplexesCopperHeterocyclic CompoundsMethaneOrganometallic CompoundsAntiviralsCopper complexesOrganometallic compoundsSARS-CoV-2

Identifiers

PMID41354887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.