Metabolic syndrome reduces but does not eliminate the cardioprotective effect of adaptation to hypoxia: the link with changes in the opioid system.

Natalia V Naryzhnaya, Ivan A Derkachev, Boris K Kurbatov, Alexander V Mukhomedzyanov, Mikhail Kilin, Artur Kan, Alexandr E Grab, Alla A Boschenko, Leonid N Maslov

Abstract read

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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalia V NaryzhnayaCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation. natalynar@yandex.ru.ORCID 0000-0003-2264-1928

Ivan A DerkachevCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0003-1998-0873

Boris K KurbatovCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0001-9603-822X

Alexander V MukhomedzyanovCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0003-1808-556X

Mikhail KilinCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0002-4300-5763

Artur KanCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0002-6418-1643

Alexandr E GrabCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0009-0005-7528-3476

Alla A BoschenkoCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0001-6009-0253

Leonid N MaslovCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 A, Kievskaya Str, Tomsk, 634012, Russian Federation.ORCID 0000-0002-6020-1598

Funding

Russian Science Foundation 22-15-00048-П, https://rscf.ru/en/project/22-15-00048/.

6 · The paper itself

Abstract

Chronic continuous hypoxia (CCH) demonstrates a pronounced protective effect in cardiac ischemia-reperfusion (IR). Opioids and opioid receptors play a significant role in this process. It has been previously shown that metabolic syndrome (MS) impairs the development of adaptive myocardial resistance to IR. The aim of this study is to identify the relationship between the cardioprotective effect of CCH and opioid peptides in circulating blood and myocardial tissue, as well as the expression of opioid receptors in the myocardium of rats with and without MS. All rats were subjected to coronary artery occlusion (45 min) and reperfusion (2 h). Some rats received high carbohydrate high fat diet for 90 days (MS) before IR. Some animals were exposed to CCH (21 days, 12% O

Indexed as

Adaptation, PhysiologicalHypoxiaMetabolic SyndromeMyocardial Reperfusion InjuryOpioid PeptidesReceptors, OpioidAnimalsDynorphinsEnkephalin, MethionineMaleMyocardiumRatsRats, WistarDynorphinsEnkephalin, MethionineOpioid PeptidesReceptors, OpioidChronic hypoxiaIschemiaMyocardiumOpioidsReperfusion

Identifiers

PMID41354854

DOI10.1007/s00424-025-03144-x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.