Evidence map›Paper›PMID 41354738›Full record

Trial reportNature communications2025

Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial.

Linmar Rodríguez-Guilarte, Constanza Méndez, Antonia Reyes, Mariana Rios, Francisca Román, Daniela Moreno-Tapia, Alex Cabrera, Daniela B Rivera, Cristián Gutiérrez-Vera, Pablo A Palacios and 29 more

Abstract readRandomized Controlled TrialClinical Trial, Phase III
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Linmar Rodríguez-GuilarteMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Constanza MéndezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Antonia ReyesMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Mariana RiosMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Francisca RománMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Daniela Moreno-TapiaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Alex CabreraFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Daniela B RiveraMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Cristián Gutiérrez-VeraMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Pablo A PalaciosMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Andrea SchillingFacultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.ORCID http://orcid.org/0000-0002-8339-779X
Sofia AljaroFacultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.ORCID http://orcid.org/0000-0002-7749-3611
Francisca BascurFacultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Álvaro RojasDepartamento de Enfermedades Infecciosas del Adulto, División de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Constanza Del RíoDepartamento de Enfermedades Infecciosas del Adulto, División de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Patricio AstudilloDepartamento de Enfermedades Infecciosas del Adulto, División de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-2600-630X
Carlos M PerezFacultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.
Loreto PerezFacultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.
Maite OyonarteDepartamento de Medicina Interna Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Patricia E Fernández VásquezDepartamento de Medicina Interna Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rosa M FeijooDepartamento de Medicina Interna Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Daniel Beltrán CamposHospital Puerto Montt, Puerto Montt, Chile.
Carlos Tovar De SousaHospital Puerto Montt, Puerto Montt, Chile.
Andrea CastejónHospital Puerto Montt, Puerto Montt, Chile.
Silvana GrandónHospital Puerto Montt, Puerto Montt, Chile.
Marcela VillarroelHospital Puerto Montt, Puerto Montt, Chile.
Pía JaraHospital Puerto Montt, Puerto Montt, Chile.
Loreto TweleHospital Puerto Montt, Puerto Montt, Chile.
M Angélica DomínguezSchool of Public Health, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
José V González-AramundizDepartamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
María Javiera Álvarez-FigueroaDepartamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Wanqi YangSinovac Biotech Co. Ltd, Beijing, China.
Qianqian XinSinovac Life Sciences Co. Ltd, Beijing, China.
Leandro J CarreñoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.ORCID http://orcid.org/0000-0003-2037-7158
Mario CalvoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Susan M BuenoMillennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Hernán F PeñalozaMillennium Institute on Immunology and Immunotherapy, Santiago, Chile. hfpenalo@uc.cl.
Pablo A GonzálezMillennium Institute on Immunology and Immunotherapy, Santiago, Chile. pagonzam@uc.cl.ORCID http://orcid.org/0000-0001-7709-6870
Alexis M KalergisMillennium Institute on Immunology and Immunotherapy, Santiago, Chile. akalergis@uc.cl.

Funding

NCIPC CDC HHS U17 CE002021
6 · The paper itself

Abstract

Annual vaccination is an effective strategy for preventing severe disease caused by seasonal influenza. Quadrivalent influenza vaccines (QIVs) protect against two strains of influenza A and two strains of influenza B, thereby enhancing the host antiviral neutralizing antibody response and inducing CD4

Indexed as

Immunity, CellularImmunity, HumoralInfluenza, HumanInfluenza VaccinesAdolescentAdultAntibodies, NeutralizingAntibodies, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDouble-Blind MethodFemaleHemagglutination Inhibition TestsHumansInfluenza A virusInfluenza B virusAntibodies, NeutralizingAntibodies, ViralInfluenza VaccinesVaccines, Inactivated

Identifiers

PMID41354738
PMCPMC12796199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.