Trial reportLasers in medical science2025
Er:YAG and Nd:YAG-based low-level laser therapy (LLLT) with medical collagen improve third-molar extraction wound healing: a randomized controlled trial.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate whether Er: YAG surgery and Nd: YAG-based low-level laser therapy (LLLT), combined with medical collagen, improve early postoperative outcomes after extraction of impacted mandibular third molars. Adults undergoing surgical removal of mesioangular or horizontal impacted mandibular third molars were randomized equally (1:1:1:1) to blank control (BCG), collagen only (COL), lasers only (LAS), or collagen plus lasers (COL + LAS). Primary endpoints were pain (VAS; spontaneous and swallowing; POD1/3/7), swelling (POD1/3/7), trismus (POD1/3/7), and early mucosal healing (POD3/7). Secondary endpoints were bleeding (30 min post-extraction only), cutaneous induration/ecchymosis (POD7), alveolar osteitis (POD3/7), and local cytokines (IL-1β, IL-6, TNF-α; POD3/7). In 120 patients, COL + LAS was superior: less pain, swelling, and trismus at POD1/3 and higher early mucosal-healing rates at POD3/7 than BCG, COL, or LAS; by POD7, between-group differences in pain, swelling, and trismus were minimal. All active arms reduced 30-min bleeding versus BCG. At POD7, cutaneous induration was lowest with COL + LAS (ecchymosis not significant). Cytokines declined overall; IL-1β and TNF-α were lowest with COL + LAS at POD3/7, whereas IL-6 decreased similarly across active arms. Er: YAG surgery plus Nd: YAG-based LLLT with medical collagen improved short-term recovery after impacted mandibular third-molar surgery.
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